Fig. 1: Structural disorganization of the retina in homozygous Pax6Leca2 mice. | Communications Biology

Fig. 1: Structural disorganization of the retina in homozygous Pax6Leca2 mice.

From: PAX6 mutation alters circadian rhythm and β cell function in mice without affecting glucose tolerance

Fig. 1

a–h′ Representative immunofluorescence images displaying a, b expression of NEUN, c, d BRN3A, e, f Melanopsin, and g–h′ merged images of eyes and eye-like structures of 20-week-old male mice. n = 4. Arrow and arrowheads depict cell types as specified in the text. Scale bar, 100 µm. i Relative mRNA expressions of circadian genes in hypothalamus at different ZTs (normalized to WT ZT0) as specified in 14–16-week-old male mice. n = 4 (WT ZT0 n = 5, Leca2 ZT6 n = 3). p values in parentheses described in the graphs were acquired by applying CircWave analysis.

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