Fig. 2: Loss of circadian rhythm in Pax6Leca2 mice. | Communications Biology

Fig. 2: Loss of circadian rhythm in Pax6Leca2 mice.

From: PAX6 mutation alters circadian rhythm and β cell function in mice without affecting glucose tolerance

Fig. 2

a–d Indirect calorimetry measurements taken over 72 h displaying (WT n = 19, Leca2 n = 13) a oxygen consumption, b average oxygen consumption (***p < 0.001 one-way Welch’s ANOVA followed by Dunnett’s post-hoc test), c locomotor activity, and d average locomotor activity (***p < 0.001 one-way Welch’s ANOVA followed by Dunnett’s post-hoc test). Gray shade and black bars depict lights off and white shade and bars depict lights on. Fourteen-week-old male mice were used for this study. Temporal measurements of plasma corticosterone in e and melatonin in f at different ZTs as specified (WT n = 8, Leca2 n = 7). (*p < 0.05, **p < 0.01, ***p < 0.001 two-way ANOVA followed by Bonferroni’s post-hoc test. Thirteen- to fifteen-week-old male mice were used for this study. Error bars display ±s.e.m.

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