Fig. 3: Pax6Leca2 mice display normal glucose tolerance in spite of impaired insulin secretion. | Communications Biology

Fig. 3: Pax6Leca2 mice display normal glucose tolerance in spite of impaired insulin secretion.

From: PAX6 mutation alters circadian rhythm and β cell function in mice without affecting glucose tolerance

Fig. 3

a Temporal measurement of blood glucose levels. b Average ad libitum body weight. Fourteen-week-old mice were used for these experiments. n = 9, *p < 0.05, **p < 0.01, ***p < 0.001 Student’s t-test and two-way ANOVA followed by Bonferroni’s post-hoc test. c Oral glucose tolerance test (oGTT) and d insulin measurements during the oGTT. WT n = 21 (c), n = 19 (d), Leca2 n = 12, **p < 0.01, ***p < 0.001 two-way ANOVA followed by Bonferroni’s post-hoc test. Total islet protein content of insulin (n = 9) in e and glucagon (n = 4) in f. *p < 0.05, **p < 0.01 Student’s t-test. g Glucose stimulated insulin secretion assay. WT n = 6, Leca2 n = 4, *p < 0.05, **p < 0.01 Student’s t-test. Ten- to twelve-week-old mice were used for these experiments. Error bars display ±s.e.m. in a, c, d, rest ±s.d.

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