Fig. 5: Decreased hepatic glucose production in Pax6Leca2 mice. | Communications Biology

Fig. 5: Decreased hepatic glucose production in Pax6Leca2 mice.

From: PAX6 mutation alters circadian rhythm and β cell function in mice without affecting glucose tolerance

Fig. 5

a, b Linear regression model displaying a fat mass and b lean mass plotted against body mass of 14-week-old male mice. WT n = 23. Leca2 n = 25. c Intraperitoneal insulin tolerance test. WT n = 7, Leca2 n = 8, **p < 0.01, ***p < 0.001 Welch’s t-test and two-way ANOVA followed by Bonferroni’s post-hoc test. d–f Results from hyperinsulinemic-euglycemic clamp displaying d Glucose infusion rate (*p < 0.05, **p < 0.01, ***p < 0.001 two-way ANOVA followed by Bonferroni’s post-hoc test), e glucose uptake by peripheral tissues, and f hepatic glucose production (***p < 0.001 one-way ANOVA followed by Bonferroni’s post-hoc test). n = 7, 12–14-week-old male mice were used. Error bars display ±s.e.m. in c, d and ±s.d. in e–f.

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