Fig. 6: MUC1-ST macrophages are present in the stroma surrounding primary breast cancers. | Communications Biology

Fig. 6: MUC1-ST macrophages are present in the stroma surrounding primary breast cancers.

From: Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype

Fig. 6

a Sequential sections stained for MUC1-ST (brown) and CD163 (brown) by IHC and SERPINE1 (blue/green) by RNAscope. b Manual scoring of SERPINE1 expression in different indicated regions of healthy ducts (within n = 12 of breast cancer cases) and tumours (n = 53 breast cancer cases). c SERPINE1 manual scores in different indicated regions of the tumour measured against MUC1-ST manual scoring (n = 53 breast cancer cases). d Example image of CD68+ CXCL5+ double staining; double positive cells are displayed as yellow as indicated by arrows. e CD68+ CXCL5+ manual scores in different indicated regions of the tumour measured against MUC1-ST scoring (n = 24 breast cancer cases). Standard error of the mean shown and paired t test used for statistical analysis. Correlations were analysed using linear regression analysis (Pearson’s). **p < 0.01, ***p < 0.001.

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