Fig. 7: Dose–response curves of wild-type and PfNek1 mutant Plasmodium strains treated with Hesperadin. | Communications Biology

Fig. 7: Dose–response curves of wild-type and PfNek1 mutant Plasmodium strains treated with Hesperadin.

From: Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases

Fig. 7

Strains analysed are indicated in the legend. They were wild-type laboratory strains (Dd2, 3D7), a strain bearing a complete PfNek1-HA fusion (Nek1 1057:HA), a Hesperadin-resistant spontaneous mutant (Dd2 8E6) and two transfectant clones with a Nek1 truncation at amino acid 853 (2F11 and 1G2). All data points are shown, slightly offset along the x-axis to avoid overlap. Lines connect the average inhibition values at each Hesperadin concentration. Data are available in Supplementary Data 1.

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