Table 2 Hesperadin IC50 of PfNek1 truncations.

From: Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases

Genetic background

Strain or clone

Hesperadin IC50 (µM)

3D7 Nek1:HA

Drug-sensitive control

0.005 ± 0.002

3D7 Nek1D(854-1057):HA

1G2

1.9 ± 0.4

3D7 Nek1D(854-1057):HA

2F11

1.8 ± 0.5

Dd2 Nek1 (854 stop)

Original resistant mutant

2.03 ± 0.06

  1. Data are averages of three biological experiments, each with three technical replicates, plus or minus the SEM.
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