Fig. 2: Pico145 binds to a conserved TRPC4/5 lipid-binding site. | Communications Biology

Fig. 2: Pico145 binds to a conserved TRPC4/5 lipid-binding site.

From: Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

Fig. 2

a Density observed in our hTRPC5:Pico145 structure (100 µM Pico145; contour level: 0.0621). b Equivalent density in the published mTRPC5 apo structure (PDB 6aei, EMDB 9615) that was modelled as a phospholipid (contour level: 0.0510). c The same site in the published mTRPC4 structure (PDB 5z96, EMDB 6901; contour level: 0.0331).

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