Fig. 3: Analysis of the Pico145-binding site of TRPC5. | Communications Biology

Fig. 3: Analysis of the Pico145-binding site of TRPC5.

From: Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

Fig. 3

a The refined structure of the Pico145-binding site within the cryo-EM density map (grey; contour level 0.0583). The binding site spans two monomers: monomer 1 is shown in orange and monomer 2 is shown in blue; Pico145 is shown in magenta. Key residues in the binding site (L521, Y524, C525, L572, Q573, W577, T603, G606 and V610) are labelled. b Chemical structure of Pico145 with the numbering of the xanthine core. c An overlay of the top docking pose of Pico145 (peach) and our fitted Pico145 molecule (magenta). The top three docking poses are shown in Supplementary Fig. 7. d The top-scoring docking pose suggests that Pico145 hydrogen bonds to Q573 and W577 (dashed blue lines) and π-stacks with F576 (dashed black line).

Back to article page