Table 2 Summary of data in Fig. 4.
TRPC5 variant | Residue in TRPC4/1/3/6/7 | EA EC50 (nM) | AM237 EC50 (nM) |
|---|---|---|---|
Wild-type | 5.7 | 10.6 | |
Q573T | Q/F/K/K/K | 260 | 110 |
F576A | F/F/F/F/F | ≥1400 | No response up to 5 µM |
W577A | W/W/W/W/W | 370 | No response up to 5 µM |
TRPC5 variant | Residue in TRPC4/1/3/6/7 | EA EC50 (nM) | AM237 EC50 (nM) |
|---|---|---|---|
Wild-type | 5.7 | 10.6 | |
Q573T | Q/F/K/K/K | 260 | 110 |
F576A | F/F/F/F/F | ≥1400 | No response up to 5 µM |
W577A | W/W/W/W/W | 370 | No response up to 5 µM |
