Fig. 8: Effect of DPc10 on Ca2+ sparks, CaM-RyR2 interaction, and hypertrophic signaling. | Communications Biology

Fig. 8: Effect of DPc10 on Ca2+ sparks, CaM-RyR2 interaction, and hypertrophic signaling.

From: Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling

Fig. 8

a Incorporation of fluorescently labeled DPc10 along the Z line in cardiomyocytes. b Ca2+ sparks. N = 18–31 cells from 3 hearts. c Fluorescence signal of RyR2-bound endogenous CaM. N = 19–25 cells from 3 hearts. d Translocation of HDAC. N = 38–50 cells from 3 hearts. e Translocation of NFAT. N = 36–53 cells from 3 hearts. Values for individual mice are plotted together with mean ± SEM. Parentheses indicate the number of mice. *P < 0.05, ***P < 0.001 (one-way ANOVA with post-hoc Tukey’s multiple comparison test).

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