Fig. 2: NE cells present an epithelial phenotype.

A Pairwise correlations between the expression profiles of 12,861 epithelial cells (rows, column) from 6 CRPC samples (color bar). Correlations were calculated across 63 lineage-specific genes (Supplementary Table 2). B Enrichment scores for gene lists including basal, luminal, NE, AR, stemness, and EMT pathway associated genes. Cells were ordered as in (A). Green indicates a low score and purple indicates a high score. C Average inferred CNV signals of corresponding cells in (A). Black indicates the high CNV signal (Supplementary Fig. 3). D UMAP visualization of all 12,861 epithelial cells for the 6 patients with cells colored by the gradient of NE score (top) and average CNV signal (bottom). The minimum score is indicated by light gray and the maximum score is indicated by blue (top) or black (bottom). E UMAP visualization of all 12,861 epithelial cells from 6 patients with color-coded for the sample origin which kept concordant with (A).