Fig. 3: Intratumor heterogeneity analyses reveal different extents of NE differentiation. | Communications Biology

Fig. 3: Intratumor heterogeneity analyses reveal different extents of NE differentiation.

From: Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

Fig. 3

A UMAP visualization of epithelial cell sub-clusters from each sample. B Heatmap depicting prostate lineage marker genes and AR pathway gene expression levels in epithelial cell sub-clusters from each sample. Those highlighted in red frame showed cluster 5 in patient #4 and cluster 4 in patient #6 was NE sub-clusters. C Immunohistochemistry (IHC) staining for K5, K18, AR, SYP, and SOX2 in sections from five samples. Scale bars represent 50 μm.

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