Fig. 1: Integrative subtypes of MIBC. | Communications Biology

Fig. 1: Integrative subtypes of MIBC.

From: Integrative multi-omics analysis of muscle-invasive bladder cancer identifies prognostic biomarkers for frontline chemotherapy and immunotherapy

Fig. 1

a Heatmaps of driver genomic features. Somatic mutation: mutated and normal genes are represented by black and white colors, respectively. Copy number: red, white, and blue represent potential copy number gain, normal, and loss, respectively. Methylation: red and blue represent hypermethylation and hypomethylation, respectively; Driver genes were grouped into two clusters M1 and M2. mRNA: red and blue represent high and low expression, respectively. Driver genes were grouped into two clusters E1 and E2. b Top enriched biological processes in methylation cluster M2. c Top enriched biological processes in mRNA expression clusters E1 (red dots) and E2 (blue dots). The numbers of genes belonging to biological processes are shown in the dots.

Back to article page