Fig. 5: DX-52-1 results in declining hearing sensitivity, as assessed by the compound action potential of the auditory nerve.
From: Radixin modulates the function of outer hair cell stereocilia
a CAP amplitudes as a function of stimulus level at 8 kHz. b CAP amplitudes as a function of stimulus frequency. c Grand average ± s.e.m (dotted) of the CAP waveforms to 60 dB SPL stimuli shows reduction in N1 and N2 amplitudes. d Averaged time courses of the changes seen in N1 amplitude measured at 60 dB SPL 8-kHz stimulus following DX-52-1 application, relative to those before the application, which decreased significantly after 15–20 min of application. e The latency of the CAP N1 increased slightly after DX-52-1 application. f Representative waveforms of the CM potential, before and after 20 min of application of 1 mM DX-52-1. The stimulus was a 8-KHz tone burst at 90 dB SPL. Data information: DMSO (n = 10), DX-52-1 (n = 18). Data are mean ± s.e.m. ****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05; ns, not significant; two-way ANOVA coupled to the Bonferroni post hoc test, two-tailed unpaired t-test with Welch’s correction.
