Fig. 1: LLPS in heterochromatin and genome organization.
From: Biomolecular condensates as arbiters of biochemical reactions inside the nucleus
a HP1 proteins associate with H3K9Me3 marks (red), oligomerize, and mediate the LLPS of heterochromatin. b Factors controlling the LLPS of nucleosome arrays. Biomolecular condensates formed by chromatin are modulated by several factors. Addition of the linker histone H1 (blue) and MeCP2 (red) proteins results in the formation of distinct and immiscible condensates. Acetylation of histone tails leads to the dissolution of the condensate, resulting in a more dispersed arrangement of the nucleosomes. Chromatin condensates can be reassembled upon the addition of bromodomain-containing proteins (green).
