Fig. 6: Illustration of the free-energy binding landscape of C5a binding to C5aR. | Communications Biology

Fig. 6: Illustration of the free-energy binding landscape of C5a binding to C5aR.

From: Submolecular probing of the complement C5a receptor–ligand binding reveals a cooperative two-site binding mechanism

Fig. 6

ΔGbu gives the free-energy difference between the ligand-bound and unbound states and is indicated for each binding site (binding site, effector site, and binding site + effector site) by vertical arrows. A positive allosteric interaction is measured when both binding sites (binding site and effector site) are occupied, as revealed by a significantly higher ΔGbu for the full binding of the C5a.

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