Fig. 4: MTPA modulates the tumor immune microenvironment towards a “hot” phenotype. | Communications Biology

Fig. 4: MTPA modulates the tumor immune microenvironment towards a “hot” phenotype.

From: Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma

Fig. 4

scRNAseq of the intratumoral myeloid compartment was performed following sublethal hyperthermia treatment of syngeneic rat HCC tumors. Cluster characterization by marker genes (a, b) and gene set analysis (c) demonstrate a significant shift in myeloid cells from M2 towards an M1 phenotype with hyperthermia relative to control. In addition, bulk RNAseq following MTPA of orthotopic liver tumors was notable for upregulation of numerous interferon-stimulated genes (d) relative to untreated tumor.

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