Fig. 4: TWAS identifies multiple hits at chromosome 5q13.2 for NEUT#. | Communications Biology

Fig. 4: TWAS identifies multiple hits at chromosome 5q13.2 for NEUT#.

From: Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation

Fig. 4

a Regional association of TWAS hits with NEUT#. The top panel in each plot highlights all genes in the region. The marginally associated TWAS genes are shown in blue and the jointly significant genes are shown in green. The bottom panel shows a regional Manhattan plot of the GWAS associations for each SNP before (gray) and after (blue) conditioning on the predicted expression of the green genes. Two-sided P-value computed from GWAS statistics. b Predicted gene expression correlation (corr.) matrix among TWAS hits at chromosome 5q13.2. c Box plots of normalized gene expression stratified by representative eQTL genotypes in CD16+ neutrophils. eQTLs were identified by using linear regression model and additive genotype effects. NEUT#, neutrophil count; Chr, chromosome.

Back to article page