Table 1 33 independent transcriptome-wide significant loci at least 500 kb away from any GWAS-identified variants.
No. | Region | Jointly significant gene | Type | Best GWAS SNP | Best GWAS P-value | Conditional P-value | TWAS Z-score | TWAS P-value |
|---|---|---|---|---|---|---|---|---|
1 | 1p35.2 | LAPTM5 | Protein | rs10737353 | 4.18E−07 | 5.60E−04 | 4.599 | 4.24E−06 |
2 | 1q42.12 | CNIH4 | Protein | rs12740255 | 5.77E−08 | 1.000 | −5.122 | 3.03E−07 |
3 | 2p23.3 | FAM228A | Protein | rs2543662 | 7.19E−09 | 1.90E−04 | 4.807 | 1.53E−06 |
4 | 2p11.2 | ELMOD3 | Protein | rs4832163 | 3.32E−07 | 0.222 | -4.982 | 6.29E−07 |
5 | 3p21.31 | SCAP | Protein | rs11920354 | 1.03E−08 | 7.70E−03 | 5.068 | 4.03E−07 |
6 | 3q25.1 | MED12L | Protein | rs4603933 | 3.64E−04 | 4.60E−03 | −5.038 | 4.71E−07 |
7 | 3q27.1 | ABCC5 | Protein | rs3749440 | 5.13E−08 | 0.202 | −5.391 | 6.99E−08 |
8 | 4q31.3 | FAM160A1 | Protein | rs361197 | 7.58E−07 | 1.60E−03 | −5.211 | 1.88E−07 |
9 | 5q35.3 | CLK4 | Protein | rs6866344 | 2.06E−07 | 0.130 | −4.794 | 1.63E−06 |
10 | 6p21.31 | ZNF76 | Protein | rs914547 | 1.42E−08 | 1.000 | 5.390 | 7.03E−08 |
11 | 6q14.1 | TENT5A | Protein | rs915125 | 4.36E−07 | 8.90E−05 | 5.348 | 8.87E−08 |
12 | 6q22.32 | CENPW | Protein | rs2184968 | 2.53E−06 | 1.000 | 4.833 | 1.35E−06 |
13 | 6q23.3 | PEX7 | Protein | rs9373174 | 2.19E−07 | 8.70E−03 | −4.542 | 5.57E−06 |
14 | 7q11.21 | GUSB | Protein | rs937108 | 1.04E−06 | 1.000 | 5.050 | 4.43E−07 |
15 | 9p24.2 | VLDLR | Protein | rs1970074 | 1.12E−07 | 4.50E−06 | 4.735 | 2.19E−06 |
16 | 9q21.2 | PRUNE2 | Protein | rs680775 | 2.31E−06 | 1.000 | 4.541 | 5.60E−06 |
17 | 9q21.32 | HNRNPK | Protein | rs7047907 | 2.90E−08 | 1.000 | 5.316 | 1.06E−07 |
18 | 9q32 | SLC31A2 | Protein | rs10121164 | 2.25E−08 | 2.90E−04 | 5.016 | 5.27E−07 |
19 | 9q34.3 | FCN1 | Protein | rs11103600 | 4.60E−06 | 0.620 | 4.846 | 1.26E−06 |
20 | 11p11.2 | MYBPC3 | Protein | rs10838748 | 5.18E−08 | 4.78E−02 | −5.129 | 2.91E−07 |
21 | 11q12.1 | AP001257.1 | lincRNA | rs11230180 | 2.28E−08 | 1.000 | 5.086 | 3.66E−07 |
22 | 12q15 | LYZ | Protein | rs2168029 | 1.23E−08 | 0.942 | −6.426 | 1.31E−10 |
23 | 14q13.2 | AL121594.1 | Protein | rs12100841 | 2.04E−06 | 1.000 | 4.817 | 1.45E−06 |
24 | 14q24.1 | SLC39A9 | Protein | rs12884741 | 2.54E−08 | 1.000 | 5.519 | 3.41E−08 |
25 | 15q22.31 | IGDCC4 | Protein | rs4539547 | 6.88E−06 | 0.430 | 4.918 | 8.74E−07 |
26 | 16p11.2 | XPO6 | Protein | rs169524 | 6.71E−06 | 0.112 | −4.477 | 7.57E−06 |
27 | 17p13.1 | ACAP1 | Protein | rs35776863 | 4.21E−07 | 1.000 | 4.958 | 7.11E−07 |
28 | 17q25.1 | SRSF2 | Protein | rs2240772 | 8.66E−07 | 1.50E−02 | 4.567 | 4.94E−06 |
29 | 18q21.1 | C18orf25 | Protein | rs8095374 | 1.00E−08 | 2.39E−03 | −5.364 | 8.16E−08 |
30 | 19q13.2 | TIMM50 | Protein | rs8107194 | 1.01E−05 | 4.69E−02 | −4.574 | 4.80E−06 |
31 | 20q13.33 | ARFRP1 | Protein | rs381331 | 3.04E−07 | n.a. | −4.738 | 2.15E−06 |
32 | 21q22.3 | PKNOX1 | Protein | rs11700748 | 1.25E−06 | 0.939 | 5.638 | 1.72E−08 |
33 | 21q22.3 | PCNT | Protein | rs2839183 | 1.69E−06 | 2.54E−02 | −4.561 | 5.08E−06 |
