Table. 1 Novel iron homeostasis associated variants found in the meta-analysis of Icelandic, UK, and Danish data, excluding variants that are only associated with ferritin.

From: A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

Marker

Position (hg38)

Min/maj

MAF (%)

Gene

Phenotype

The effect in SD (95% CI)

P value

Phet

rs35945185

chr1:65671556

A/G

36.5

LEPRa

Iron

0.031 (0.023, 0.039)

1.54 × 10−13

0.00130

rs469882

chr1:91064875

C/A

20.8

ZNF644

TIBC

−0.037 (−0.048, −0.026)

1.03 × 10−10

0.566

rs2228145

chr1:154454494

C/A

40.7

IL6Ra

Iron

0.026 (0.018, 0.034)

8.42 × 10−11

0.107

rs6025

chr1:169549811

T/C

2.79

F5a

Ferritin

0.15 (0.12, 0.17)

6.93 × 10−37

7.90 × 10−9

     

TIBC

−0.093 (−0.13, −0.061)

1.76 × 10−8

0.227

rs13007705

chr2:238160555

T/C

42.5

ERFE

Iron

0.029 (0.021, 0.037)

2.01 × 10−12

0.717

     

TSAT

0.033 (0.024, 0.042)

1.10 × 10−12

0.0539

rs7630745

chr3:66376605

C/T

35.8

LRIG1a

Iron

0.025 (0.017, 0.033)

2.09 × 10−9

0.924

rs59950280

chr4:3450618

A/G

33.5

HGFAC

TIBC

0.033 (0.023, 0.043)

5.87 × 10−11

0.729

rs9399136

chr6:135081201

C/T

25.9

MYBa

Iron

0.057 (0.049, 0.066)

1.08 × 10−36

0.492

     

TIBC

−0.033 (−0.044, −0.023)

2.65 × 10−10

0.483

     

TSAT

0.067 (0.057, 0.077)

5.32 × 10−39

0.130

rs12718598

chr7:50360747

C/T

46.3

IKZF1

Iron

0.027 (0.019, 0.034)

3.69 × 10−11

0.126

rs17580

chr14:94380925

A/T

3.79

SERPINA1a

TIBC

0.076 (0.053, 0.099)

1.19 × 10−10

0.811

rs57659670

chr15:45106240

C/T

7.53

DUOX2a

Ferritin

−0.14 (−0.16, −0.13)

1.05 × 10−113

0.0361

     

Iron

−0.042 (−0.056, −0.028)

1.08 × 10−8

0.0708

     

TSAT

−0.058 (−0.074, −0.041)

5.73 × 10−12

0.876

     

TIBC

0.077 (0.06, 0.094)

3.67 × 10−19

0.434

rs77262773

chr17:69253570

T/C

2.61

ABCA5

Iron

0.081 (0.055, 0.11)

9.54 × 10−10

0.130

rs2005682

chr19:35456759

T/A

30.5

HAMP

TSAT

−0.032 (−0.042, −0.022)

6.25 × 10−11

0.126

     

Iron

−0.029 (−0.037, −0.02)

2.37 × 10−11

0.270

rs112727702

chr19:49587947

T/G

23.2

PRRG2

TIBC

0.043 (0.032, 0.054)

2.08 × 10−14

0.849

rs1132274

chr20:17615510

A/C

16.8

RRBP1a

TIBC

0.036 (0.023, 0.048)

1.93 × 10−8

0.0837

  1. aHigh-confidence predicted causal gene (based on a variant-to-gene algorithm, see “Methods”).
  2. Min/maj minor/major allele, MAF minor allele frequency, Gene predicted causal gene based on a variant-to-gene algorithm (see “Methods”), SD standard deviation, CI confidence interval, Phet P value from the test for heterogeneity (see “Methods”), TIBC total iron-binding capacity, TSAT transferrin saturation. The effect is shown for the minor allele.
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