Fig. 1: DCN inhibits in vitro tumorigenic features in IBC cell lines. | Communications Biology

Fig. 1: DCN inhibits in vitro tumorigenic features in IBC cell lines.

From: Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer

Fig. 1

a Generation of four DCN-overexpressing IBC stable cell lines [HER2+: MDA-IBC3, SUM190; TNBC: SUM149, BCX010]. Total cell lysates were analyzed by western blotting with anti-DCN and anti-GAPDH antibody. b–f DCN overexpression in IBC cell lines suppresses colony formation (b), cell migration in SUM149 and BCX010 cells (c), cell invasion in SUM149 and BCX010 cells (d), primary mammosphere formation (e), and secondary mammosphere formation (f). g–i Treating IBC cell lines with recombinant DCN protein (8 μg/mL) suppresses colony formation (g), cell migration (h), and cell invasion (i). Scale bar: 100  μm. P values are from Student’s unpaired t tests. Data are presented as mean ± s.e.m.; Data shown are representative of three independent experiments.

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