Fig. 3: modRNA treated BMSCs combined with biomaterials enhance bone healing in rat cranial defect model. | Communications Biology

Fig. 3: modRNA treated BMSCs combined with biomaterials enhance bone healing in rat cranial defect model.

From: BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways

Fig. 3

(a-) Schematic of experimental design (a) and cranial defect surgery process (b). c Representative images reconstructed from 3D μCT scans reveals bone tissue regeneration at 4 and 12 wks after treatment. d, e Quantified bone volume fraction (BV/TV) of regenerated bone at 4 wks (d) and 12 wks (e) post-implantation. Differences between modRNA treatments and control group were assessed by one-way ANOVA followed by Tukey’s multiple comparison. Dollar ($) indicate difference between acellular collagen scaffold group and other four groups. Hash (#) indicate difference between non-transfected and transfected groups. Asterisk (*) indicate difference among modRNA transfection groups. (Values are expressed as mean ± SD, $/#/*p < 0.05, $$/##/**p < 0.01, $$$/###/***p < 0.001).

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