Fig. 1: A conserved DNA methylation system in chicken.
From: A chicken DNA methylation clock for the prediction of broiler health
a Conservation of canonical DNMT enzymes in chicken. Conserved domains of animal DNMTs are shown in different colors. All DNMTs: catalytic domain (red). DNMT1: DMAP1 binding domain (dark blue), replication foci targeting domain (orange), CXXC domain (turquoise), BAH domain (green). DNMT3: PWWP domain (pink), ADD domain (purple). DNMT3L is a catalytically inactive DNMT3 variant that lacks the N-terminal part of the regulatory domain (including the PWWP domain) and the C-terminal part of the catalytic domain. b Evolutionary conservation of DNMT3L in vertebrates. The phylogenetic tree is based on 421 automatically annotated genomes from NCBI/refseq. c Interspecific comparison of somatic methylation landscapes. Violin plots show methylation ratios of 2 kb sliding windows covering the entire genome. The uneven plot shape for the elephant shark (Callorhinchus milii) is related to the relatively low sequencing coverage. The DNMT homologs of individual organisms are indicated under the respective species names.
