Fig. 7: Baseline and post-administration (57 min from last treatment offset) concentrations of plasmatic oxytocin in each treatment condition.

We conducted a linear mixed model on plasmatic oxytocin concentrations measured in a blood sample collected immediately before the beginning of the resting-state acquisition, using Time, Treatment and Time × Treatment as fixed factors and a random intercept for subject. We followed up the significant interaction with further post-hoc tests to examine differences between each pair of treatment conditions between baseline and post-administration and between treatment conditions within each time level, using Tukey’s correction for multiple testing. In the upper panel, we present box and violin plots depicting the distribution of plasmatic concentrations of oxytocin for each treatment condition and time point; middle horizontal lines represent the mean; boxes indicate the 25th and 75th percentiles (n = 16 per treatment condition and time point). In the lower panel, we present the descriptive statistics for each level of the two factors. *Intravenous condition compared to the other three (p < 0.01) at post-administration; # Spray and Nebuliser conditions compared to placebo (<0.001) at post-administration.