Fig. 4: An excessive response lability underlies the reversal learning deficit.
From: A cross-species assessment of behavioral flexibility in compulsive disorders
a Deficits of behavioral flexibility found in both OCD “checkers” patients (n = 21) and “impaired” KO mice (n = 12) subgroups were not explained by a greater perseveration (in term of reversal errors). b Instead, both OCD “checkers” and “impaired” KO mice showed an increased SSC probability compared to other groups (n = 19 “non-checkers”, 40 healthy controls, 14 “unimpaired” KO and 26 WT mice), suggesting a higher response lability. ncOCD: “non-checkers”. cOCD: “checkers”. uKO: “unimpaired” KO mice. iKO: “impaired” KO mice. Triangle: group mean. Dot: individual mean. Ø: BF10 < 1. *BF10 < 3. *BF10 ≥ 3. **BF10 ≥ 10. ***BF10 ≥ 30. ****BF10 ≥ 100.
