Table 1 Humans and mice behavioral parameters in the reversal learning task.
From: A cross-species assessment of behavioral flexibility in compulsive disorders
Humans | ||||||
|---|---|---|---|---|---|---|
Healthy (H) | OCD | BF10 | Checkers (C) | Non-checkers (NC) | BF10ANOVA | |
Trials in acquisition phase | 19.79 (7.29) | 24.09 (9.89) | 2.29 | 28.13 (11.59) | 19.62 (4.74) | 47.88: C > NC = H |
Trials to reversal | 26.09 (6.84) | 29.09 (8.43) | 0.64 | 31.87 (10.05) | 26.02 (4.8) | 3.98: C > NC = H |
Reversal errors | 1.64 (0.4) | 1.48 (0.27) | 1.5 | 1.46 (0.26) | 1.51 (0.28) | 0.72 |
SSC probability as % | 4.1 (3.17) | 5.2 (4.68) | 0.41 | 6.47 (5.44) | 3.8 (3.27) | 1.19: C > NC = H |
SSC errors | 0.17 (0.19) | 0.17 (0.16) | 0.17 | 0.21 (0.17) | 0.12 (0.15) | 0.35 |
SCAPE probability as % | 54.79 (22.53) | 61.82 (15.26) | 0.6 | 61.86 (14.78) | 61.77 (16.17) | 0.33 |
SCAPE errors | 1.28 (0.16) | 1.29 (0.21) | 0.19 | 1.31 (0.25) | 1.26 (0.15) | 0.16 |
C57BL/6J mice | ||||||
|---|---|---|---|---|---|---|
WT (W) | Sapap3 KO | BF10 | Impaired KO (I) | Unimpaired KO (U) | BF10ANOVA | |
Trials in acquisition phase | 464.66 (182.23) | 438.39 (248.19) | 0.22 | 560.08 (261.76) | 334.07 (187.31) | 2.35: U < I = W |
Trials to reversal | 437.7 (156.89) | 554.39 (290.37) | 0.7 | 746.87 (278.55) | 389.4 (181.61) | >100: W = U < I |
Reversal errors as % | 25.84 (12.8) | 22.08 (12.97) | 0.44 | 11.1 (5.17) | 31.49 (9.71) | >100: I < U = W |
SSC probability as % | 44.19 (3.65) | 44.4 (4.09) | 0.21 | 48.1 (1.88) | 41.22 (2.36) | >100: U < W < I |
SSC errors | 0.57 (0.11) | 0.45 (0.09) | 27.74 | 0.41 (0.08) | 0.48 (0.1) | >100: I < U < W |
