Fig. 1: Structure of initial AZD4320-dendrimer conjugates. | Communications Biology

Fig. 1: Structure of initial AZD4320-dendrimer conjugates.

From: Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

Fig. 1

Overall schematic of PEG2100 containing AZD4320-dendrimer conjugates showing structure and chemical structure of highlighted quadrant. Conjugation sites and synthetic route allow for a maximum of 32 conjugated PEG molecules (grey ovals) and 32 AZD4320 molecules (red dots) per dendrimer (blue circle). Variability in linker (pink rectangle): X = CH2 for SPL-8931, X = S for SPL-8932 and X = O for SPL-8933.

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