Fig. 4: Cardiovascular effects of AZD4320 and AZD4320-dendrimer conjugates in rat. | Communications Biology

Fig. 4: Cardiovascular effects of AZD4320 and AZD4320-dendrimer conjugates in rat.

From: Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

Fig. 4

Time course of changes in QRS amplitude in telemetered rats following single dose IV administration at t = 0 h of a vehicle (0 mg/kg) AZD4320, (black diamonds) and AZD4320 (red squares), n = 6-8 per group. b Control dendrimer (black diamonds) SPL-8931 (orange squares) and SPL-8932 (red circles), n = 3 per group. Data are group mean ± SEM.

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