Fig. 4: Efficacy of E8 in human ex vivo organ cultures (EVOC).
From: Discovery of tumoricidal DNA oligonucleotides by response-directed in vitro evolution
E8 was administered to EVOCs freshly derived from TNBC patients (two representative patients, P1 and P2, are shown). a, b E8 and other chemotherapies were administered. E8 was administered at 50 μM, while the chemotherapeutic drugs were administered at their respective therapeutic doses. Treatment was given 1/d for 2 d, and samples were fixed at 5 d, sections were made and stained with hematoxylin-eosin. Effects were graded by 2 blinded pathologists on a 0–4 scale. White stars denote the experimental groups in which effect reached a grade of at least 3, and relate to the entire respective column. Rnd, random oligonucleotide; magnifications are shown in the bottom left corners of each row. Scale bars: A, upper and lower scale bar, 200 μm. B, upper scale bar, 1 mm; lower scale bar, 200 μM.
