Fig. 1: Deletion of IFT20 in osteoblast lineage impairs the bone microarchitecture. | Communications Biology

Fig. 1: Deletion of IFT20 in osteoblast lineage impairs the bone microarchitecture.

From: Primary cilia control cell alignment and patterning in bone development via ceramide-PKCζ-β-catenin signaling

Fig. 1

Micrographs of 3D-reconstructed µCT trabecular bones representing 1-month-old femurs dissected from paraformaldehyde fixed IFT20f/f control mice (n = 3) (a, c) and IFT20f/f; Col1cre-ERT mice (n = 3) (b, d). Quantitative analysis of the percentage of bone volume to total bone volume (BV/TV) (e), trabecular thickness (Tb.Th) (f), trabecular number (Tb.N) (g), and trabecular spacing (Tb.Sp) (h), bone mineral density (BMD) (i), and Triangulation-Structure Model Index (TRI-SMI) (j) in the distal femurs. Micrographs of 3D-reconstructed µCT trabecular bones representing 3-months-old femurs dissected from paraformaldehyde fixed OSX-cre control mice (n = 3) (k, m) and IFT20f/f;OSX-cre mice (n = 9) (l, n). Quantitative analysis of the percentage of bone volume to total bone volume (BV/TV) (o), trabecular thickness (Tb.Th) (p), trabecular number (Tb.N) (q), trabecular spacing (Tb.Sp) (r), bone mineral density (BMD) (s), and Triangulation-Structure Model Index (TRI-SMI) (t) in the distal femurs. Student t-test were performed and the p values are indicated in the histograms. Scale bar (a, b, k, l) 100 μm. Scale bar (c, d, m, n) 1 mm.

Back to article page