Fig. 2: Deletion of IFT20 impairs osteoblast organization and alignments in cortical bone. | Communications Biology

Fig. 2: Deletion of IFT20 impairs osteoblast organization and alignments in cortical bone.

From: Primary cilia control cell alignment and patterning in bone development via ceramide-PKCζ-β-catenin signaling

Fig. 2

Hematoxylin and eosin (H&E) staining of longitudinal sections of tibia in tamoxifen injected IFT20f/f (a, c) and IFT20f/f; Col1-creERT (b, d). Trabecular bones are clearly reduced in the IFT20 deleted mice (b) compared to the control mice (a). The cell arrangement in the cortical bones is more organized in the IFT20 intact animals (c) than the IFT20 deleted animals (d). H&E staining of tibia sections from OSX-cre (e, g) and IFT20; OSX-cre mice (f, h). There are less trabecular bones found in the IFT20 deleted mice (f) compared to Osx-cre control mice (e). The cell arrangements in the cortical are persistently more organized in the Osx-cre controls (g) than the IFT20 deleted mice (h). Scale bar (a, b, e, f) 500 μm. Scale bar (c, d, g, h) 25 μm.

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