Fig. 5: Mitochondrial regional plots indicating genotype–phenotype associations identified by PheWAS.
From: Genetic and phenotypic landscape of the mitochondrial genome in the Japanese population
Regional association plots of the entire mtDNA illustrating the genotype–phenotype associations identified by the mitochondrial PheWAS in the Japanese population (n = 147,310). Y-axes represent –log10(P) of the associations of the variants and x-axes represent the base pair positions in mtDNA. An upper horizontal bar in each plot represents the study-wide significance threshold of P = 2.5 × 10−6, considering multiple comparisons of both the numbers of the variants and phenotypes. A lower horizontal bar in each plot represent the study-wide significance threshold of P = 2.4 × 10−4, considering multiple comparisons of the number of the variants. Mitochondrial gene positions are indicated in the bottom panel.
