Fig. 4: The sharing of pleiotropic variants between Cholesky-transformed (CT) traits.
a The sharing of pleiotropic variants related to each CT trait, variantstrait, between pairs of CT traits. The numbers in parentheses are the assigned pleiotropic variantstrait for each CT trait based on the true combinations of trait by variant prioritised by EDME. The numbers in boxes are the number of variants in the overlap between pairs of CT traits. Red boxes indicate that the sharing of pleiotropic variantstrait between CT traits is significantly different from random based on hypergeometric tests (accounting for the number of pleiotropic variantstrait assigned for each trait and the total number of selected variants). b The ranking of CT traits using the sharing index of pleiotropic variantstrait, calculated as the number of overlap over the number of union for each CT trait pair, averaged across the other 33 traits. The y-axis has three columns separated by ‘|’ that are defined from left to right as: the CT trait name, the order of the Cholesky transformation and the number of pleiotropic variantstrait assigned to that CT trait. The x-axis indicates the average sharing index of pleiotropic variantstrait. Error bars indicates the standard error of the average of the sharing index of pleiotropic variantstrait across 33 CT traits.
