Fig. 1: RNA-seq and connectivity Map (CMAP) analysis of differentially expressed genes (DEG) in Fmr1 knockout (KO) hippocampal neuron. | Communications Biology

Fig. 1: RNA-seq and connectivity Map (CMAP) analysis of differentially expressed genes (DEG) in Fmr1 knockout (KO) hippocampal neuron.

From: Transcriptome signature analysis repurposes trifluoperazine for the treatment of fragile X syndrome in mouse model

Fig. 1

a Gene expression differences between wild type (WT) and Fmr1 KO samples. There are 587 upregulated and 724 downregulated genes in Fmr1 KO hippocampal neuron. b Top 15 GO biology processes that are associated with DEG between WT and Fmr1 KO samples. c KEGG pathways that are associated with DEG between WT and Fmr1 KO samples. d Top-ranked 10 CMAP compounds/drugs that induce transcriptome alterations oppositional to (indicated by negative similarity mean) or overlapping with (indicated by positive similarity mean) that caused by Fmr1 deficiency. Rank is determined by P value and enrichment score. Drug name and cell line indicate the name of compound used for treatment with specific cell lines in CMAP database. Full information of P value, enrichment score, and similarity mean is shown in Supplementary Data 5.

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