Fig. 7: Fmr1 KO neurons are more sensitive to trifluoperazine treatment. | Communications Biology

Fig. 7: Fmr1 KO neurons are more sensitive to trifluoperazine treatment.

From: Transcriptome signature analysis repurposes trifluoperazine for the treatment of fragile X syndrome in mouse model

Fig. 7

DIV 14 wild type (WT) (a) and Fmr1 KO neurons (b) were treated with trifluoperazine (TFP) at various concentrations (as indicated). Following the 1 h treatment, levels of pAkt, total Akt, and β-actin were determined by Western blot. The level of pAkt is normalized to the level of total Akt. The relative level of pAkt in the vehicle-treated control group is defined as 1, and all samples are normalized to this group. The p value between the indicated group and the vehicle-treated control group was determined by one-way ANOVA (F5,12 = 17.777, p = 0.000 for a; F5,12 = 33.545, p = 0.000) for (b) followed by post hoc Tukey’s test.

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