Fig. 2: Accurate reproduction of the ReW features in SOTRs using a mathematical model. | Communications Biology

Fig. 2: Accurate reproduction of the ReW features in SOTRs using a mathematical model.

From: Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring

Fig. 2

a Examples of simulation results of the model (upper panel) and the activation map (lower panel). For the group with zero ReW, an action potential initiates from the left position of the ring and propagates in the opposite directions along the ring, after which the two waves meet and annihilate on another. The process starts again with new waves initiating at the same position periodically. For groups with one, two, or three ReWs, stable ReWs travel around the ring. Membrane potential and activation time are color coded. b The percentage of stable ReWs in SOTRs at day 6 (diameter = 3 mm; n = 60 in the simulation and n = 204 biologically independent samples in the experiment). c Beat rate (Hz) and d ReW speed in SOTRs with one ReW at day 6 for different pillar diameters [experiment: 1-mm SOTR (n = 4); 3-mm SOTR (n = 12); 5-mm SOTR (n = 10 biologically independent samples)]. **P < 0.001 (ANOVA). e Speeds of one, two, or three ReWs in SOTRs with a pillar diameter of 3 mm [experiment: mean ± s.d.; 3 ReWs (n = 4); 2 ReWs (n = 10); 1 ReW (n = 12 biologically independent samples)]. *P < 0.05; **P < 0.001 (ANOVA). f The maximum number of ReWs in SOTRs with different pillar diameters.

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