Table 5 Pathway analyses of genes implicated in GxE interaction effects of low-frequency hearing upon vocabulary development.
Pathway ID | Pathway description | No. Genes | P (FDR) | Matching genes |
|---|---|---|---|---|
GO processes | ||||
GO.0007155 | Cell adhesion | 21 | 0.00254 | APP,BTN3A1,CADM2,CDH18,CDH26,CLDN11,CLSTN2,CNTNAP2,COL13A1,FAT3,FOXP1,GPR56,ITGA9,ITGBL1,NUAK1,PDGFRA,PRKCA,PRKCE,PTPRK,PTPRM,SEMA5A |
GO.0051270 | Regulation of cellular component movement | 17 | 0.00842 | ANK2,CAMK1D,DACH1,FOXP1,GPR56,MAGI2,NTRK3,PDGFRA,PLXNA4,PRKCA,PRKCE,PTPRK,PTPRM,SCN5A,SEMA5A,SYNE1,SYNE2 |
GO functions | ||||
GO.0005515 | Protein binding | 50 | 0.0382 | AGBL1,ANK2,ANLN,APP,BCL2L1,CDYL,CLDN11,CNTNAP2,CPE,DEPDC5,DLG2,DMRT3,ELMO1,ESR1,ESRRG,EXOC4,FCRL2,FOXP1,GPR56,LRRFIP1,MAGI2,MAP7,MECOM,MICALCL,NTRK3,NUAK1,PAX5,PCCA,PDGFRA,PHACTR4,PRAME,PRKCA,PRKCE,PTPRK,PTPRM,RAB11FIP4,RAD23B,RALYL,SCN5A,SEMA5A,SEPT7,SPPL2C,STXBP6,SYNE1,SYNE2,TLR1,TP73,TRIM33,USH2A,WWOX |
GO cellular components | ||||
GO.0071944 | Cell periphery | 58 | 4.87E-06 | ADCY9,ANK2,ANLN,APP,BNC2,BTN3A1,CADM2,CDC42BPB,CDH11,CDH18,CDH26,CLDN11,CLSTN2,CNTNAP2,COL13A1,COL23A1,CPE,DLG2,DPP10,ELMO1,EPN1,ESR1,FAT3,FCRL2,FCRL3,GPHN,GPR56,HTR1E,KCNJ1,LGR5,LRRFIP1,LYPD6B,MAGI2,MAP7,MCF2L,MDGA2,MGAM,NTRK3,PDGFRA,PLEK2,PLXNA4,PRAME,PRKCA,PRKCE,PTPRK,PTPRM,PTPRN2,RIMBP2,SCN5A,SEMA5A,SEPT7,SLC22A3,SLC7A14,STXBP6,SYNE1,SYNE2,TLR1,USH2A |
GO.0005886 | Plasma membrane | 57 | 4.87E-06 | ADCY9,ANK2,APP,BNC2,BTN3A1,CADM2,CDC42BPB,CDH11,CDH18,CDH26,CLDN11,CLSTN2,CNTNAP2,COL13A1,COL23A1,CPE,DLG2,DPP10,ELMO1,EPN1,ESR1,FAT3,FCRL2,FCRL3,GPHN,GPR56,HTR1E,KCNJ1,LGR5,LRRFIP1,LYPD6B,MAGI2,MAP7,MCF2L,MDGA2,MGAM,NTRK3,PDGFRA,PLEK2,PLXNA4,PRAME,PRKCA,PRKCE,PTPRK,PTPRM,PTPRN2,RIMBP2,SCN5A,SEMA5A,SEPT7,SLC22A3,SLC7A14,STXBP6,SYNE1,SYNE2,TLR1,USH2A |
GO.0016020 | Membrane | 76 | 0.00523 | ADCY9,ANK2,APP,ARHGAP15,ASTN2,ATRNL1,BCL2L1,BNC2,BTN3A1,CADM2,CDC42BPB,CDH11,CDH18,CDH26,CLDN11,CNTNAP2,COL13A1,COL23A1,CPE,CSMD1,DEPDC5,DLG2,DPP10,DPYSL2,EIF3H,ELMO1,EPN1,ESR1,FAT3,FCRL3,GPHN,GPR56,HTR1E,INPP5D,KCNJ1,KIAA1024,LGR5,LINGO2,LRRFIP1,LYPD6B,MAGI2,MAP7,MCF2L,MDGA2,MGAM,MGAT4C,MTMR7,NTRK3,PDE10A,PDGFRA,PLEK2,PLXNA4,PRAME,PRKCA,PRKCE,PTPRK,PTPRM,PTPRN2,RAB11FIP4,RIMBP2,SCN5A,SEMA5A,SEPT7,SLC22A3,SLC37A2,SLC7A14,SLC9A9,SORCS2,SPPL2C,STT3A,STXBP6,SYNE1,SYNE2,THSD7B,TLR1,USH2A |
GO.0044459 | Plasma membrane part | 31 | 0.00523 | ADCY9,ANK2,APP,CLSTN2,CNTNAP2,COL13A1,DLG2,EPB41L3,EXOC4,FCRL2,GPHN,GPR56,HTR1E,KCNJ1,LGR5,MAP7,MGAM,NTRK3,PDGFRA,PLEK2,PTPRK,PTPRM,PTPRN2,SCN5A,SLC22A3,SLC6A6,SLC7A14,SYNE1,SYNE2,TLR1,USH2A |
GO.0033267 | Axon part | 8 | 0.00523 | APP,CNTNAP2,DLG2,DPYSL2,EPB41L3,EPN1,PTPRN2,SEPT7 |
GO.0044224 | Juxtaparanode region of axon | 3 | 0.00869 | CNTNAP2,DLG2,EPB41L3 |
GO.0031252 | Cell leading edge | 10 | 0.0126 | CDC42BPB,CNTNAP2,EPB41L3,MCF2L,PHACTR4,PLEK2,PTPRK,PTPRM,SYNE1,SYNE2 |
GO.0005911 | Cell–cell junction | 10 | 0.0126 | ANK2,APP,CDC42BPB,CLDN11,COL13A1,EPB41L3,MAGI2,PTPRK,PTPRM,SCN5A |
GO.0031256 | Leading edge membrane | 6 | 0.0236 | CNTNAP2,EPB41L3,PLEK2,PTPRK,SYNE1,SYNE2 |
GO.0030054 | Cell junction | 18 | 0.0236 | ANK2,APP,BCL2L1,CADM2,CDC42BPB,CLDN11,COL13A1,DLG2,EPB41L3,GPHN,MAGI2,PTPRK,PTPRM,RIMBP2,SCN5A,SYNE1,SYNE2,TP73 |
GO.0045202 | Synapse | 13 | 0.0236 | ANK2,BCL2L1,CADM2,CLSTN2,DPYSL2,EPB41L3,EPN1,GPHN,MAGI2,PTPRN2,RIMBP2,SEPT7,SYNE1 |
GO.0031224 | Intrinsic component of membrane | 53 | 0.0237 | ADCY9,ANK2,APP,ASTN2,ATRNL1,BCL2L1,BTN3A1,CADM2,CDH11,CDH18,CDH26,CLDN11,CLSTN2,CNTNAP2,COL13A1,COL23A1,CSMD1,DPP10,ESR1,FAT3,FCRL2,FCRL3,GPR56,HTR1E,KCNJ1,KIAA1024,LGR5,LINGO2,LYPD6B,MDGA2,MGAM,MGAT4C,NTRK3,PDGFRA,PLXNA4,PTPRK,PTPRM,PTPRN2,SCN5A,SEMA5A,SLC22A3,SLC37A2,SLC7A14,SLC9A9,SORCS2,SPPL2C,STT3A,STXBP6,SYNE1,SYNE2,THSD7B,TLR1,USH2A |
GO.0044425 | Membrane part | 58 | 0.0257 | ADCY9,ANK2,APP,ASTN2,ATRNL1,BCL2L1,BTN3A1,CADM2,CDH11,CDH18,CDH26,CLDN11,CNTNAP2,COL13A1,COL23A1,CSMD1,DLG2,DPP10,EPB41L3,EPN1,ESR1,EXOC4,FAT3,FCRL3,GPHN,GPR56,HTR1E,KCNJ1,KIAA1024,LGR5,LINGO2,LYPD6B,MAP7,MDGA2,MGAM,MGAT4C,NTRK3,PDGFRA,PLEK2,PLXNA4,PTPRK,PTPRM,PTPRN2,SCN5A,SEMA5A,SLC22A3,SLC37A2,SLC7A14,SLC9A9,SORCS2,SPPL2C,STT3A,STXBP6,SYNE1,SYNE2,THSD7B,TLR1,USH2A |
GO.0031258 | Lamellipodium membrane | 3 | 0.0288 | PLEK2,SYNE1,SYNE2 |
GO.0098805 | Whole membrane | 24 | 0.039 | ANK2,APP,BCL2L1,CLSTN2,CNTNAP2,CPE,DEPDC5,DLG2,EPB41L3,EPN1,GPHN,ITGA9,MAP7,MGAM,PLEK2,PTPRN2,RAB11FIP4,SCN5A,SLC7A14,SLC9A9,SYNE1,SYNE2,TLR1,USH2A |
GO.0016021 | Integral component of membrane | 51 | 0.039 | ADCY9,ANK2,APP,ASTN2,ATRNL1,BCL2L1,BTN3A1,CADM2,CDH11,CDH18,CDH26,CLDN11,CLSTN2,CNTNAP2,COL13A1,COL23A1,CSMD1,DPP10,ESR1,FAT3,FCRL2,FCRL3,GPR56,HTR1E,KCNJ1,KIAA1024,LGR5,LINGO2,MGAM,MGAT4C,NTRK3,PDGFRA,PLXNA4,PTPRK,PTPRM,PTPRN2,SCN5A,SEMA5A,SLC22A3,SLC37A2,SLC7A14,SLC9A9,SORCS2,SPPL2C,STT3A,STXBP6,SYNE1,SYNE2,THSD7B,TLR1,USH2A |
GO.0042995 | Cell projection | 22 | 0.039 | ANK2,CADM2,CLSTN2,CNTNAP2,DPYSL2,EPB41L3,EPN1,EXOC4,GPR56,MAGI2,MCF2L,PDGFRA,PHACTR4,PLEK2,PRKCA,PTPRK,PTPRM,PTPRN2,SYNE1,SYNE2,TSPEAR,USH2A |
GO.0030424 | Axon | 9 | 0.0452 | CADM2,CNTNAP2,DLG2,DPYSL2,EPB41L3,EPN1,PTPRK,PTPRN2,SEPT7 |
