Fig. 1: Trehalose metabolism functions in glucose homeostasis.
a Overview of trehalose and glucose metabolism. Proteins that function in trehalose metabolism are shown in red. b Schematic representation of the Tps1 locus. Protein-coding regions and untranslated regions are represented by black boxes and white boxes, respectively. The Minos insertion site is marked with an inverted triangle. c Amounts of trehalose, glucose, glycogen, and TAG in Tps1MIC mutants at the wandering stage. d Circulating sugar levels under various dietary conditions. ND, normal diet; LG, low-glucose diet; HG, high-glucose diet; Glc, glucose. Composition of diets is shown in Fig. 5a. *p < 0.05, **p < 0.01, ***p < 0.001; unpaired two-tailed Student’s t-test (c), unpaired two-tailed Student’s t-test with Bonferroni correction (d). Results are presented as the mean ± SD. The numbers indicate the number of biological replicates.
