Fig. 6: HSA exposed to CPA shows reduced hFcRn binding.
From: An intact C-terminal end of albumin is required for its long half-life in humans
a Relative hFcRn binding at pH 5.5 of HSA variants exposed (striped bars) or nonexposed (white bars) to CPA. Calculated from ELISA results in (b) and in Supplementary Fig. 6, where nonexposed was set to 1. The data are shown as the mean ± s.d. of three independent experiments where n = 2. b ELISA showing binding to hFcRn at pH 5.5 of WT HSA (circle) and K573P (triangle) that had been exposed (filled black) or not exposed (filled white) to CPA.
