Fig. 1: Quinolone activities measured with MIC and DEK vary according to their capacity of membrane translocation and sensibility to efflux. | Communications Biology

Fig. 1: Quinolone activities measured with MIC and DEK vary according to their capacity of membrane translocation and sensibility to efflux.

From: The challenge of intracellular antibiotic accumulation, a function of fluoroquinolone influx versus bacterial efflux

Fig. 1

Quinolone activities measured on the efflux-deficient mutant (AG100A) were plotted on the x axis (influence of the capacity of membrane translocation on activities) against the ratio of activities measured on the efflux-proficient compared with the -deficient mutant (AG102/AG100A) plotted on the y axis (influence of the AcrAB efflux pump sensibility on activities). a Red squares, MIC values. b Blue circles, DEK (dose necessary for early killing) values. See also Supplementary Table 1. To optimize the readability of the figure, the abscissa is represented as a logarithmic scale, and the quinolone names are abbreviated as mentioned in Table 1.

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