Fig. 8: KH-3 inhibits breast cancer growth and metastasis in vivo. | Communications Biology

Fig. 8: KH-3 inhibits breast cancer growth and metastasis in vivo.

From: Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis

Fig. 8

a In vivo anti-tumor efficacy of KH-3 in MDA-MB-231 orthotopic xenograft model. KH-3 treatment significantly inhibits the tumor growth compared to the vehicle control (n = 12, **P < 0.01, ***P < 0.001, two-way ANOVA). b Protein expression levels of HuR and downstream targets in tumor tissues after treatment. α-Tubulin is used as loading control. c, d Kaplan–Meier analysis of the initiation of pulmonary metastases (c) and overall survival of mice (d) comparing treatment with vehicle control or KH-3 in an experimental metastasis model (n = 9, *P < 0.05, **P < 0.01, log-rank test). e Schematic of screening for HuR inhibitors that bind to HuR and block HuR function. f Proposed working model of KH-3 inhibiting breast cancer invasion and metastasis.

Back to article page