Fig. 5: Experimental and computational models predict L4 pyramidal neuron dendritic bursting is associated with the alpha rhythm.

a Upper panel shows somatic response to 500 ms, 0.2 nA depolarising current injection in L4 V1 pyramids in drug-free slices and their corresponding computational model. Note the generation of spike doublets and triplets and the presence of a large afterdepolarisation. Middle panel shows example somatic behaviour over four consecutive periods of the alpha rhythm, again demonstrating a highly variable numbers of spikes per period. Lower panel shows an overlay of spike profiles for 10 alpha rhythm periods to illustrate the variable timing of additional spikes per period when they occur. Scale bars 10 mV, 100 ms (upper and middle panels), 10 ms (lower panel). b Upper panel shows dendritic response to 500 ms, 0.2 nA depolarising current injection in L4 V1 pyramids in drug-free slices and their computational model. Note the generation of complex dendritic bursts and partial spikes. Middle panel shows example dendritic behaviour over four consecutive periods of the alpha rhythm, again demonstrating variable dendritic burst and partial spikes per alpha period. Lower panel shows an overlay of partial spike-burst profiles for 10 alpha rhythm periods to illustrate the variable nature of the dendritic burst discharges. Scale bars 5 mV, 100 ms (upper and middle panels), 20 ms (lower panel).