Fig. 1: Overall structure and subunit interactions of the HsLRRC8D hexamer. | Communications Biology

Fig. 1: Overall structure and subunit interactions of the HsLRRC8D hexamer.

From: Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation

Fig. 1

a The overall structure of the HsLRRC8D hexamer, viewed parallel to the membrane (left) and from the extracellular (right, upper) and intracellular (right, lower) sides. b A subunit of the HsLRRC8D structure, viewed parallel to the membrane. According to the previously proposed HsLRRC8A hexamer structure (PDB ID: 5ZSU)15, each region is colored as follows: NTH dark gray, TM1 purple, EL1 blue, TM2 light blue, IL1 cyan, TM3 green, EL2 light green, TM4 yellow, IL2 orange, LRRNT red, LRR1-15 pink, and LRRCT brown. The N- and C-termini are indicated by ‘N’ and ‘C’, respectively. The molecular graphics were illustrated with CueMol (http://www.cuemol.org/).

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