Fig. 2: Comparisons of the HsLRRC8D and HsLRRC8A structures.

a, b Overall structures of the HsLRRC8D (a) and HsLRRA8A (PDB ID: 5ZSU)15 (b) hexamers, viewed parallel to the membrane (left) and from the intracellular side (right). c Superimposition of the HsLRRC8D (colored according to Fig. 1b) and the HsLRRC8A (gray) structures, using the Cα atoms of the protomers. The structures are depicted in cylinder representations with molecular surfaces.