Fig. 2: Different MF-GrC properties: synaptic responsiveness and S/N. | Communications Biology

Fig. 2: Different MF-GrC properties: synaptic responsiveness and S/N.

From: Parameter tuning differentiates granule cell subtypes enriching transmission properties at the cerebellum input stage

Fig. 2

Three exemplar GrC cell recordings are shown, one adapting, one non-adapting, one accelerating, as defined by their intrinsic electroresponsiveness (same cells and color codes as in Fig. 1). a Voltage responses of exemplar GrCs to electrical stimulation of the MF bundle (1 s continuous stimulation at 20 Hz followed by 250 ms at 100 Hz) from the holding potential of –65 mV. b Plot of the synaptic frequency change SFC vs. stimulus frequency for the three GrCs shown in a (each line represents a GrC with the same color code as in a). A positive peak is apparent in the accelerating GrC at 20 Hz background stimulation, while negative SFC values prevail in the other GrCs. c Signal-to-noise ratio, (S/N = fresp@100 Hz/fresp@20 Hz) for the three GrCs in a, b. Note that S/N is much higher in adapting that in the other two GrCs.

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