Fig. 7: Prediction of the ionic mechanisms of firing adaptation and acceleration. | Communications Biology

Fig. 7: Prediction of the ionic mechanisms of firing adaptation and acceleration.

From: Parameter tuning differentiates granule cell subtypes enriching transmission properties at the cerebellum input stage

Fig. 7

a The graph shows the distribution of IFC in GrC models with respect to the Cav2.2 maximum conductance (mS/cm2), revealing a negative correlation (R2 = 0.88, n = 150, p < 10–4). At the level of GrC subtypes, there is a clear unbalance of Cav2.2 maximum conductance in favor of adapting GrCs. b The traces show the voltage and intracellular Ca2+ concentration along with ionic currents in non-adapting and strong-adapting GrCs during 10 pA current injection at 1700 ms. Double arrows measure the difference between non-adapting and strong-adapting GrCs. A scheme showing the hypothetical mechanisms differentiating the two cell subtypes is reported in Supplemental Material. c The traces show the voltage and intracellular Ca2+ concentration along with ionic currents and elements of the intracellular coupling mechanism in an accelerating GrCs during 10 pA current injection. A scheme showing the chemical reactions, leading to TRPM4 channel opening is reported in Supplemental Material.

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