Fig. 5: Anhydrotetracycline and analogues inhibit enzymatic inactivation of latest-generation tetracyclines by Tet(X7).

a In vitro, anhydrotetracycline, anhydrochlortetracycline, and anhydrodemeclocycline inhibit Tet(X) modification of tigecycline. Likewise, anhydrotetracycline and anhydrodemeclocycline inhibit in vitro enzymatic modification of tigecycline (b), eravacycline (c), and omadacycline (d) by Tet(X7). Error bars represent standard deviation for three independent trials.