Table 3 Anhydrodemeclocycline at subinhibitory concentrations can partially rescue tetracycline, tigecycline, eravacycline, and omadacycline efficacy against Pseudomonas aeruginosa Pa-3, E. coli DH10B heterologously expressing Tet(X7), Pseudomonas aeruginosa ATCC 27853, and E. coli DH10B with an empty pZE21 vector.

From: Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance

 

Pseudomonas aeruginosa Pa-3

Escherichia coli DH10β + tet(X7)

Pseudomonas aeruginosa ATCC 27853

Escherichia coli DH10β + pZE21

Antibiotic

MIC- 0 µg/mL aDem

MIC- 8 µg/mL aDem

MIC- 0 µg/mL aDem

MIC- 8 µg/mL aDem

MIC- 0 µg/mL aDem

MIC- 8 µg/mL aDem

MIC- 0 µg/mL aDem

MIC- 8 µg/mL aDem

Tetracycline

128

32

256

128

32

32

8

4

Tigecycline

64

64

32

2

8

8

1

1

Eravacycline

64

32

8

8

16

16

1

1

Omadacycline

256

256

64

8

128

128

1

1

  1. In total, 8 µg/ml anhydrodemeclocycline is equivalent to 18 µM anhydrodemeclocycline.
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