Fig. 3: Evidence for Ido1-expressing Paneth cells in human CRC and early adenomas.
From: IDO1+ Paneth cells promote immune escape of colorectal cancer
a IHC staining for STAT1 and IDO1 on consecutive tissue microarray (TMA) sections of human CRC. A tubular structure with cancer cells showing co-expression of STAT1 and IDO1 is indicated by arrowheads in the lower images (scale bars 50 µm). b Correlation matrix of TCGA expression data for Stat1, Ido1, IRDS genes, and markers for Paneth, Goblet, enteroendocrine, and cancer stem cells in human CRC. c IF staining for Lysozyme (LYZ) and IDO1 of a human adenoma biopsy of a FAP patient. The perinuclear signal for IDO1 is indicated by an arrowhead in the right high-magnification image (scale bar 50 µm). d IF staining was used for quantification of IDO1+ non-Paneth (LYZ−) and Paneth (LYZ+) cells in the neoplastic epithelium of human adenomas.
